【TITLE & POSITION】

Ph.D., Senior Professor, FBSE, FCSBM.

Member of the Teaching Steering Committee for Biomedical Engineering in Colleges

and Universities, Ministry of Education, China (October 2018–present)

Deputy Director of the Academic Committee of Chongqing University Health Science Center (December 2019 - December 2023)

Director, Key Laboratory of Biorheological Science and Technology, Ministry of

Education, China (June 2018–February 2025)

Founding Director, National Local Engineering Laboratory in Vascular Implants, National Development and Reform Commission, China (March 2015– present)

Founding Director, Public Experiment Center of National Biological Industrialization Base (Chongqing), National Development and Reform Commission, China (August 2008 – present)

Founding Director, Chongqing Engineering Laboratory in Vascular Grafts, Chongqing, China (December 2008 – December 2018)

Founding Director, Construction Base of National First-Class Characteristic Specialty in Biological Engineering, Ministry of Education, China (September 2008 - December 2012)

Associate Dean, National “985 Project” Institute of Biorheology and Gene Regulation Technique, Chongqing University, China (June 2005—May 2008)

Deputy Dean，Dean/Chairperson, College of Bioengineering, Chongqing University, China (July 2002 – April 2023)

Founding Director, Research Center of Applied Biotechnology, Chongqing University, China (January 2002 –December 2008)

September 2000—present, Professor, College of Bioengineering, Chongqing University, China

【HONORARY TITLES】

Fellow (FCSBM): Fellow of the Chinese Society for Biomaterials (2025.09-)

Fellow (FBSE): Fellow of the International Union of Societies for Biomaterials Science and Engineering (2024.5-)

World's Top 2% Scientists (Single Year, 5 times, 2021--2025) in Biomedical Engineering.

World's Top 2% Scientists (Career Long, 2025) in Biomedical Engineering.

ELSEVIER Highly Cited Chinese Researchers (RANKING Internationally Famous Scholars) in Biomedical Engineering (6 times, 2019--2024) in Biomedical Engineering.

GLOBALAUTHORID 2023 One of the World's Top 100000 Scientists (6 times, 2019--2024) in Biomedical Engineering.

Chongqing Academic and Technical Leader (2019-).

Young and Middle-aged Key Teachers of Colleges and Universities in Chongqing (2007-).

【ACADEMIC APPOINTMENTS】

Honorary Chairperson: Vascular Branch of the Chinese Society of Anatomy (2023.12 -)

Chairperson: Branch of Atherosclerosis under the Chinese Society of Pathophysiology (2021.06 -)

Chairperson: Material Biomechanics Branch of the Chinese Society for Biomaterials (2022.12 -)

Chairperson: Science and Technology Branch of Chongqing Traditional Chinese Medicine Industry Association, China (2019.01-)

Life Member: World Association for Chinese Biomedical Engineers (2016-), International Chinese Musculoskeletal Research Society (ICMRS) (2019.04 -)

Vice Chairperson: The Interventional Medicine Innovation Alliance of the National Radiology and Therapy Clinical Medical Research Center (2022.12-), Vascular Branch of Chinese Society of Anatomy (2018.9 -); Professional Committee of Interventional Medicine Engineering and Biotechnology, the Interventional Medicine Branch of the Chinese Medical Doctor Association (2018.06 -), Chinese Holistic Integrative Medicine and Engineering Alliance (2018.01-)

Executive Member of the Council: Branch of Interventional Treatment of Cardiac and Brain Diseases, China Medical Device Industry Association (2017.03--2021.03), Branch of Interventional Medical Engineering of Chinese Society of Biomedical Engineering (2007.08--2015.05), Cardiovascular Biomaterials Branch of Chinese Society for Biomaterials (2015.06-), China Branch of International Society of Atherosclerosis (2015.01-), Chongqing Biomedical Engineering Association (2006.01-).

Member of Council:, World Association for Chinese Biomedical Engineers (2024.07-), Chinese Society of Biomedical Engineering (2015.12--2019.12), Chinese Society for Biomaterials (2012.06-), the Intellectual Medical Professional Committee of the Chinese Medical Doctor Association (2018.05-), Branch of Biomechanics under Chinese Society of Biomedical Engineering and Chinese Society of Mechanics (2015.03-), Branch of Rehabilitation Engineering under Chinese Society of Biomedical Engineering (2016.07-), China Branch of International Society of Atherosclerosis (2011.04--2014.12), Branch of Zebrafish under Chinese Society of Animals (2016.09-)

Associate/Deputy Editor: Research (2024.02-), Molecular & Cellular Biomechanics (2020-), Journal of Medical and Biological Engineering (2018--2022)

Executive Member of the Editorial Board: Chinese Journal of Arteriosclerosis (2014-)

Editorial Board Members: iMeta (2025-), Biomedical Materials (2021-), Molecular & Cellular Biomechanics (2017-), Journal of Medical and Biological Engineering (2014-), AIMS Bioengineering (2014-2018), Journal of Cardiology Therapy (2014-2018), Chinese Journal of Arteriosclerosis (2009--2014)

Guest Editor-in-Chief: Frontiers in Pharmacology, Special Issue: Bioactive Substance-Mediated Targeted Therapy for Cardio-Cerebrovascular Diseases (2022)

【CONTACT INFORMATION】

Tel: 86-23-65106996(O), Fax: 86-23-65102507

Email: wanggx@cqu.edu.cn

http://bio.cqu.edu.cn/info/1164/3021.htm

【PERSONAL PROFILE】

Prof. Guixue WANG has long been engaged in basic research and applied transformation in areas such as the biomechanics of atherosclerotic cardiovascular and cerebrovascular diseases, biorheology and vascular tissue repair materials, nanomedicine delivery, and rehabilitation engineering and has been granted more than 60 Chinese and US patents. He was selected as a World's top 2% scientist (Single Year, 5 times, 2021--2025, and Career Long, 2025) in Biomedical Engineering by Elsevier. He is a Fellow of the Chinese Society for Biomaterials (FCSBM) and a Fellow of the International Union of Societies for Biomaterials Science and Engineering (FBSE). He is a recipient of the State Council Special Government Allowance and an academic leader in Chongqing, China. He has received four first prizes, five second and third prizes for provincial and ministerial-level and national industry association science and technology/teaching achievements, and one second prize for the National Science and Technology Progress Award (passed the preliminary review and public announcement, awaiting certificate issuance). He has published over 450 academic papers in Chinese and English in journals such as Nature Neuroscience, ACS Nano, Journal of Biomechanics, Biomaterials, Bioactive Materials, Research, iMeta, The Innovation, Exploration, Advanced Science, Science in China, and Science Bulletin. He has also edited or coedited 11 textbooks and monographs. He has supervised and trained 30 postdoctoral fellows, 60 doctoral students, and 120 master's students.

He has also selected as a Review Expert for the National Natural Science Foundation of China (NSFC) Outstanding Young Scientists Fund/Excellent Young Scientists Fund/Key Project/General Project/Regional Project/Youth Project/International Cooperation Project; the NSFC Thousand Talents Program; the NDRC National Medical Research and Development Innovation Platform Project; the Ministry of Education Changjiang Scholars Program/Higher Education Institutions Young Scientist Award and Teaching Award; the Ministry of Science and Technology Key Research and Development Program; the Chongqing Municipal Science and Technology Commission/NDRC/Health Commission/Education Commission/Human Resources and Social Security Bureau Science and Technology and Talent Projects; and the Reviewer and nominator for the "Science Exploration Award" project.

【RESEARCH INTERESTS】

Biomedical Engineering, Biochemistry & Molecular Biology, Biomechanics, Biomedical materials, Cell Biology, Materials Science, Atherosclerosis, Basic and clinical translational sciences, Minimally invasive medical devices, Nanodrug delivery, Nanoscience & Nanotechnology.

【REPRESENTATIVE RESEARCH PROJECTS】

A total of 47 projects at all levels have been undertaken. There were 13 projects at the national level, 28 at the provincial, ministerial, and municipal levels, and 4 horizontally. Research funding of over 70 million yuan was received, including the following most recent year projects:

“Study the effects of biomimetic nanoprodrugs on targeted anti-atherosclerosis and their mechanobiology mechanisms”. Supported by the National Natural Science Foundation of China (No. 32471366), 2025.01-2028.12, as principal investigator, 500,000 RMB

“Key Technologies for Functionalized Vascular/Heart Valve Materials and Prosthesis Construction” Supported by National Key R&D Program Projects, China (No.2023YFB3810100), 2023.11-2026.10. 30,000,000 RMB

“Study on the Mechanobiological Mechanism and Precise Diagnosis and Treatment of Cerebrovascular Diseases”, Supported by Science and Technology Innovation Project of JinFeng Laboratory (Chongqing), China (No. jfkyjf202203001), 2022.09-2026.08. 8,000,000 RMB

“Study on Cellular Mechanobiology Mechanism of Engulfment of Vascular Endothelial Cell Promoting Atherosclerosis”, Supported by Key Projects of the National Natural Science Foundation of China (No. 12032207), 2021.01-2025.12. 3,700,000 RMB

“The Role and Mechanism of Low and Oscillatory Shear Stress-downregulated TET1s Promoting Atherosclerosis Development”, Supported by the National Natural Science Foundation of China (No. 31971242), 2020.01-2023.12. 700,000 RMB

“The 7th Sino US Biomedical Engineering and Biomechanics at Home and Abroad Technical Seminar”, Supported by the Emergency Management Project of National Natural Science Foundation of China (No.11842023), 2019.07.26-2019.07.30. 8,0000 RMB.

“Study on Phenotypic Regulation and Reverse Calcification Technology during Degradation Control of Vascular Endothelial and Smooth Muscle Cell”, Supported by the National Key Technology R&D Program (No. 2016YFC1102305), 2016.01-2020.12. 1,500,000 RMB

“Mechano-Biological Mechanism Which Flow Shear Stress Regulates Vascular Development in Zebrafish”, Supported by the National Natural Science Foundation of China (No. 11572064), 2016.01-2019.12, 860,000 RMB

“Mechano-Biological Mechanism on In-stent Restenosis and Late Thrombosis Reduced by Mechanic Environments after Intravascular Stent Implanting”, Supported by Key Projects of the National Natural Science Foundation of China (No. 11332003), 2014.01-2018.12, as coprincipal investigator, 1,500,000 RMB

“Mechano-Biological Mechanism underlying High Shear Stress-Promoted Angiogenesis-Induced Vulnerable Plaque Formation”, Supported by the National Natural Science Foundation of China (No. 31370949), 2013.01-2017.12. 820,000 RMB

“The Effect and Mechanism of Mussel Protein/VE-cadherin/CD47 Fusion Protein Coating on Promoting Vascular Injury Repair”, Supported by Key Projects of the Natural Science Foundation of Chongqing Science and Technology Bureau (No. cstc2019jcyj-zdxmX0028), 2019.09- 2022.08. 800,000 RMB

【REPRESENTATIVE PUBLICATIONS】

Professor Wang has collaborated with domestic and foreign scholars to publish over 400 peer-reviewed papers in total.  Some representative papers are as follows.

1. Yan W, Li S, Zhang T, Huang J, Deng C, Yuan K, Huang N, Zhang H, Wang G. Synergistic fusion of CD47, VE-cadherin and mussel adhesion proteins promotes endothelialization and suppresses inflammation in vascular stents. Bioactive Materials 2026, 55: 257–270, DOI:10.1016/j.bioactmat.2025.09.015（IF:20.3）

2. Deng Z, Xiang Z, Zhu S, Zhang Y, Du Y, Wang S, Kang Z,Wang Z, Tong X, Liu Y, Jiang L, Malashicheva A, Sun H, Dong F, Wang G, Li C, Zang G. Switching Cathodic/Anodic Electrochemiluminescence of Ru(bpy)32+Precisely via Homogeneous Nickel Nanoparticles Crystal Facets Sites Modulated ORR/OER. Exploration, Aug 2025, 20250036, DOI: 10.1002/EXP.20250036, DOI:10.1002/imt2.70048,(IF:22.5)

3. Zeng J, Zhang Y, Gao Y, Jia M, Guo Y, Li X, Wang Y, Zhao C, Qiu J, McGinty S, Miao W, Wang G, Wang Y. Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition. ACS Nano. 2025 Jul;19(25):22968-22987.  DOI: 10.1021/acsnano.5c02492. (IF:16, , Nature Index Journal）

4. Wang C；Liu Z, Zhou T, Wu J, Feng F, Wang S, Chi Q, Sha Y, Zha S, Shu S, Qu L, Du Q, Yu H, Yang L, Malashicheva A, Dong N, Xie F, Wang G, Xu K. Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation. iMeta, 2025, e70048. DOI:10.1002/imt2.70048,（IF:33.2, ESI Highly Cited Papers, Hot paper）

5. Shi W, Yi X, Ruan H, Wang D, Wu D, Jiang P, Luo L, Ma X, Jiang F, Li C, Wu W, Luo L, Li L, Wang G, Qiu J, Huang H. An animal model recapitulates human hepatic diseases associated with GATA6 mutations. PNAS-Proc Natl Acad Sci U S A.  2025 Jan 7;122(1):e2317801121. DOI:10.1073/pnas.2317801121.（IF：9.4, Nature Index Journal）

6. Jia M, Miao M, Li Y, Guo Y, Zeng J, Gao Y, Li X, Wang Y, Zhao Z, Xu Z, Wang Z, Yang F, Zhao J, Wang Y, Wang G. Polymerized probucol nanoformulations with neutrophil extracellular vesicle camouflaging for cerebral ischaemia‒reperfusion injury therapy. The Innovation, 2024, 6(4): 100761, 2025, DOI:10.1016/ j.xinn.2024.100761. (IF:33.2)

7. Liu X, Zhao S, Tan L, Tan Y, Wang Y, Ye Z, Hou C, Xu Y, Liu S, Wang G. Frontier and hot topics in electrochemiluminescence sensing technology based on CiteSpace bibliometric analysis. Biosens Bioelectron. 2022; 201:113932. DOI: 10.1016/j.bios.2021.113932. (IF: 10.618, ESI Highly Cited Papers)

8. Qin X, Zhang K, Qiu J, Wang N, Qu K, Cui Y, Huang J, Luo L, Zhong Y, Tian T, Wu W, Wang Y, Wang G. Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude  shear stress. Bioact Mater. 2021; 9:397-410 10.1016/j.bioactmat.2021.10.038.89. (IF:16.87).

9. Wang Y, Zhang K, Li T, Maruf A, Qin X, Luo L, Zhong Y, Qiu J, McGinty S, Pontrelli G, Liao X, Wu W, Wang G. Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications. Theranostics, 2021, 11(1): 164-180. DOI: 10.7150/thno.47841. (IF:11.6, ESI Highly cited paper)

10. Zhou T, Zheng Y, Sun L, Badea S, Jin Y, Liu Y, Rolfe A, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw T, Wu W, Wang G, Ren Y.  Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neuroscience. 2019, 22(3), 421–435. DOI:10.1038/s41593-018-0324-9. (IF:21.1, Nature Index Journal, ESI Highly Cited Papers)

11. Wang Y, Zhang K, Qin X, Li T, Qiu J, Yin T, Huang J, McGinty S, Pontrelli G, Ren J, Wang Q, Wu W, Wang G. Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2019, 6(12): 1900172. 10.1002/advs.201900172. (IF:15.8, ESI Highly Cited Papers)

12. Bunggulawa J, Wang W, Yin T, Wang N, Durkan C, Wang Y, Wang G. Recent advancements in the use of exosomes as drug delivery systems. Journal of Nanobiotechnology. 2018, 16(1), 81. DOI: 10.1186/s12951-018-0403-9. (IF:10.43, ESI Highly Cited Papers)

【REPRESENTATIVE MONOGRAGHES】

Accumulated: 6 textbooks as an editor-in-chief; 1 deputy editor, 2 textbook chapters; 2 monographs as an editor-in-chief, 2 monograph as deputy editor, and 6 monograph chapters, including:

Wang G. “The Mechanobiology in Atherosclerosis: Basic, Frontier and Advance”（in English），Singapore：Springer Nature Singapore，2024.

“Clinical Research Methods”, Beijing: Electronic Industry Press, 2025, a textbook planned by the National Universities Biomedical Engineering Teaching Steering Committee. Editor-in-Chief: Wang G

“Biomedical Statistics”, Beijing: Electronic Industry Press, 2024, a textbook planned by the National Universities Biomedical Engineering Teaching Steering Committee. Editor-in-Chief: Wang G

“Advanced Biochemistry” (2nd Edition), Chongqing: Southwest Normal University Press, 2021. Co-Editor-in-Chief: Wang G

“Mechanobiological Basis and Frontiers of Atherosclerosis”, Chongqing University Press, 2020, A monograph reflecting the summary of the research results of Professor Wang and his team engaged in the mechanobiology of atherosclerosis for more than 20 years. Editor: Wang G

“Comprehensive Experiments of Bioengineering”, Beijing: Science Press, 2013. Editor-in-Chief: Wang G

“Advanced Biochemistry”, Chongqing: Southwest Normal University Press, 2010, Co-Editor-in-Chief: Wang G

“China Education Quality Assurance and Evaluation”, Beijing: National Academy of Administration Press, 2009, Associate Editor-in-Chief: Wang G

“Professional English for Biology”, Chongqing: Southwest Normal University Press, 2007, Co-Editor-in-Chief: Wang G

“Horticultural Experiments and Statistical Analysis”, Chengdu: Chengdu University of Science and Technology Press, 1994. Editor-in-Chief: Wang G

“Cosmic Holographic Exploration”, Chengdu: Chengdu University of Science and Technology Press, 1993, Editor-in-Chief: Wang G

Wang G, Qiu J. Adhesion and spreading of cells on the surface of materials. In “Biomedical Materials Science--Materials Biology” (Ch 4), Beijing: People's Health Publishing House, 2021. Editors:  Guangfu Yin and Shengmin Zhang.

Wang G, et al. Advances in hemodynamics, lipid concentration polarization and atherosclerosis. In “Advances in Atherosclerosis Research” 2012: ISBN: 978-81-308-0498-9, Research Signpost, Kerala, India. Editors: Yong-Zong Yang, Ming Zhao and Ke-Seng Zhao.

Wang G. Hemodynamic changes and atherosclerosis. In “Atherosclerotic Cardiovascular Disease Basics and Clinics” (Ch 32), Beijing: Science Press, 2009 (Second Edition) Editor-in-Chief: Yongzong Yang.

Wang G. Atherosclerosis and hemodynamic changes. In “Atherosclerotic Cardiovascular Disease Basics and Clinics”" (Ch 25), Beijing: Science Press, 2004 (First Edition) Editor-in-Chief: Yongzong Yang.

Wang G, et al.The Mechanobiology of Atherosclerosis and Interventional Therapy of Vascular Stents. In “Mechanobiology” (Ch 20), Shanghai Jiaotong University Publishing House. 2018. Editors: Zonglai Jiang and Yingxin Qi.

Wang G, et al. The Mechanobiology of Vascular Stent Endothelialization and Endothelial Injury Repair. In “Tissue Repair Biomechanics” (Ch 10), Shanghai Jiaotong University Press. 2018. Editors: Li Yang and Yonggang Lv.